Measuring Immune System Response

immune system

Measuring Immune System Response

The human immune system is highly variable between individuals and much may be learned by studying the patterns of immunology.  What does this mean to us in an age of high percentages of the population with chronic disease and vaccine and antibiotic mania?  The answer or better yet, a framework for an answer is below for this highly important question regarding our health and quality of life. Rather than using intuition or what we have heard to generate a “System 1” fast, automatic, intuitive brain solution as psychologists contemplate, we will take a “System 2” approach and lay out the complexities of the immune system.  Bear with us as “System 2” thinking requires some work, but it also always outperforms system 1 intuitive thinking.

What is the distribution of immune system markers?

We recently took a proxy of one million laboratory blood samples to measure a cross sectional sample to illustrate a range of immune system biomarkers.  Before diving into the numbers, lets probe further into “System 1” analysis and “System 2” analysis.  To illustrate system one thinking, we can take a stereotypical physician visit which suggests “you should get your influenza vaccine”.  Before we process this statement from the physician, it would be a valid system 2 response to ask, “how many times did the pharmaceutical reps buy lunch for you or your staff over the past month?”.  Such as question, can help to level the asymmetric information in such an encounter.  Most doctors allocate 5-10 minutes for a patient visit and they certainly do not help a patient understand the capability of their immune system or the level of their immune system.  This failure, would be an example of a physician making a recommendation using “System 1” as this is their trained response rather than using a “System 2” response which would require asking for questions of the patient and to understand a large cross section of data.  A small data point of many in a “System 2” analysis would know the global vaccine market is nearing $54 Billion per year on its way to $73+ Billion by 2028.

The range on infection fighting proteins (immunoglobulin) vary by as much as 10 to 1 between “healthy” people and “immune system compromised people”.  The five primary classes of immunoglobulins are IgG, IgM, IgA, IgD and IgE. These are distinguished by the type of heavy chain found in the molecule.  IgG molecules have heavy chains known as gamma-chains; IgMs have mu-chains; IgAs have alpha-chains; IgEs have epsilon-chains; and IgDs have delta-chains.

Nutrition Unpacked

Historically, immune responses have been classified as cellular or humoral. Cellular responses are mediated by T lymphocytes, which recognize and attack their targets directly or indirectly by enlisting the help of other immune cells, while humoral responses are characterized by the production of antibodies by B lymphocytes and their progeny, plasma cells.

immune system hinge antigen

INTERESTING FACT:

The influence of diet in pregnant women on the immune tolerance process is intricate. Food-specific immunoglobulin G (IgG) was associated with exposure to particular food antigens. The IgG antibodies can cross the placental barrier and enter into the colostrum, and maternal IgG is amply present in breast milk. This justifies studying the immunological connection between food-specific IgG antibodies and the mother–fetus relationship.

Heavy and light chains are held together by a combination of non-covalent interactions and covalent interchain disulfide bonds, forming a bilaterally symmetric structure. The V regions of H and L chains comprise the antigen-binding sites of the immunoglobulin (Ig) molecules. Each Ig monomer contains two antigen-binding sites and is said to be bivalent.

The hinge region is the area of the H chains between the first and second C region domains and is held together by disulfide bonds. This flexible hinge (found in IgG, IgA and IgD, but not IgM or IgE) region allows the distance between the two antigen-binding sites to vary.

Eat foods such as nuts, dark green leafy greens, sweet potatoes and avocado to get more vitamin E in your meals.  Vitamin E is known to boost immunoglobulins.  As diet and our trips to the grocery store tend to be based on “System 1” thinking where we see words that may seem healthy, we really need to approach our eating using our “System 2” thinking.  While looking at a nutrition label may seem like multiplying 24 x 57 in your head (we can’t do this using system 1 thinking), we have designed Foodie Body Search so that you upload your blood labs and then just type a food and the system does all the “System 2” math for you.  The benefit is you can get an instant “System 1” decision or information quickly, while outsourcing all the “System 2” math to the Foodie Body Search engine.

Disease Prevention

Customized Solutions for your body and chemistry

Just as epigenetics can cause issues such as metabolic syndrome, cancer, heart disease, mental disorders, auto-immune disease and diabetes, food can also ameliorate these conditions. To learn more on if the first steps of a plant based whole foods plan are right for you create a free account and review the 30 day Foodie Body plan.  There is no charge to participate and the search engine will customize your food results to help improve your independently verified labs.  Consult your physician before commencing on a dietary change to ensure it is right for you.

Biochemistry

immune system

Measuring Immune System Response

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